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It should be noted that in the second round of ALE, the evolved cells that grew in Acr-containing medium for more than 100 generations did tolerate higher concentrations of Acr, and no higher GSH-accumulating strains were obtained

FischakCKlausRWerkmeisterRMHohenadlCPrinzMSchmettererLet al

10.1002/ajmg.a.38494 72 Di CostanzoA.AngelicoR