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Examples of Bayesianbased study designs that incorporate both toxicity and efficacy include the EffTox design46 or TriCRM.47 It is also important to consider the PK/PD relationship in elucidating a biologically active dose range as supported by the task force on Methodology for the Development of Innovative Cancer Therapies.48 What else can be considered

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Neuron icon was designed by Inkscape ( To understand their therapeutic potential, it is first important to explore how astrocytes sustain neural homeostasis and how this balance can shift from protective to detrimental in disease context