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6.3 ALA Alpha-lipoic acid (ALA) is a disulfide compound with unique biochemical properties: it is both water- and fat-soluble, enabling it to act throughout the cell, and it can counteract excessive ROS induced by chronic hypoxia by neutralizing free radicals, chelating metal ions, and regenerating other antioxidant substances (such as vitamins C and E and glutathione)

( d ) Relative peak intensities of representative metabolites increased in astrocytes of the 5xFAD group compared to the control group, including malate, glutamine, cytidine and 4-acetmidobutanoate

A cysteine desulfurase (IscS) provides the sulfur, while the formation of the cluster takes place on the scaffold protein named IscU

Human gut microbiota: toward an ecology of disease