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Caution required: patients on anticoagulants (bleeding risk at injection sites), patients with a history of herpes simplex around the eyes (treatment may activate a flare), patients with unrealistic expectations or those expecting a single session to fully resolve long-standing dark circles, and patients whose dominant cause is pure tear trough volume loss (where filler is the more appropriate first-line treatment)

It has been reported to upregulate interleukin-2 (IL-2) production and modulate cytokine balance, contributing to restored immune homeostasis in models of immunodeficiency, chronic infection, and age-related thymic involution

Deletion of S100a8 and S100a9 enhances skin hyperplasia and promotes the Th17 response in imiquimod-induced psoriasis

& Kang, J