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Description
Vivarelli, S., Spatari, G., Costa, C., Giamb, F
Please store properly and prevent children from taking it by themselves
Analogue 1j [bearing N, N-dimethylamino and alkoxy substituents] maximises hydrophobic contacts in the ATP pocket notably engaging Ile294 deeply and contacting Val163 and Ala176 on the kinase hinge
Results Conserved basic residues cluster to patches on the surface of SPOC PHF3 SPOC has been established as a CTD reader domain 5 , but it has remained unknown whether CTD binding is unique to PHF3 or if other SPOC domains possess the same ability
