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In addition, BSO-induced ferroptosis can be selectively enhanced by chemicals that facilitate PDI activation or PDI-mediated iNOS dimerization or NO accumulation

In basal cell carcinomas, as well as in primary proliferating keratinocytes, Sonic hedgehog (Shh) increases the expression of D3, acting via a conserved Gli2 binding site on the human Dio3 promoter (121, 215)

ROS play important roles at the ER, where their production activates the unfolded protein response (UPR), accompanied by the inactivating sulfhydration of protein tyrosine phosphatase 1B (PTP1B) that results in the increased phosphorylation and, hence, activation of PERK 91

Correlation of the rate of protein synthesis and the third power of the RNA: protein ratio in Escherichia coli and Mycobacterium tuberculosis