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Abbreviations ALT alanine aminotransferase AMPK adenosine monophosphate-activated protein kinase AST aspartate aminotransferase Caco-2 carcinoma colon-2 COX cyclooxygenase CD cluster of differentiation Cpt1 carnitine palmitoyl transferase 1 CXCL12 CXC chemokine CXCR4 C-X-C chemokine receptor type 4 DNA deoxyribonucleic acid FAS fatty acid synthase FBA N-(1-carbamoyl-2-phenyl-ethyl) butyramide FBG fasting blood glucose FBS fasting blood sugar GLA gutliver axis GLP1 glucagon-like peptide-1 GLP-1R GLP-1 receptor GPCR G-protein-coupled receptor GSH glutathione GSSG/GSH oxidised glutathione/glutathione ratio HDAC histone deacetylase HFD high-fat diet 4-HNE 4-hydroxynonenal HOMA-IR homeostatic model assessment of insulin resistance IFN interferon IL interleukin iNOS inducible nitric oxide synthase INSIG insulin-induced gene IR insulin resistance ISI insulin sensitivity index LBP lipopolysaccharide binding protein LDL-C low-density lipoprotein cholesterol LPS lipopolysaccharide MAFLD metabolic-associated fatty liver disease MCP1 monocyte chemoattractant protein-1 MCS methioninecholine-sufficient diet MIM metabolites of intestinal microflora miR microRNA Mn-SOD manganese superoxide dismutase mRNA messenger ribonucleic acid NaB sodium butyrate NAFLD non-alcoholic fatty liver disease NAS NAFLD activity score NASH non-alcoholic steatohepatitis NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells PPAR peroxisome proliferator-activated receptor SCFAs short-chain fatty acids ROS radical oxygen species SOD1 superoxide dismutase-1 SREBP sterol regulatory element-binding protein TC total cholesterol TG triglyceride TJs tight junctions TLR toll-like receptor TNF- tumour necrosis factor WSD western-style diet