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Phosphorylation of p22phox is mediated by phospholipase D-dependent and -independent mechanisms

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The rationale for this is the fact that in any future human clinical trial with NAC a standard of care for headache could not be withheld irrespective of how the experimental protocol is organized

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The Journal of clinical investigation 112 , 608618, doi: 10.1172/JCI17305 (2003)

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These findings elucidated the multilevel regulatory consequences of ACE2KO and provided mechanistic insights into associated metabolic dysfunction

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