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J Pediatr Pharmacol Ther 19

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67 Similar observations have been reported in New Zealand and Brazilian cohorts of T2DM patients taking metformin, with age, dose, and duration of metformin treatment identified as important factors in the depletion of vitamin B 12

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High concentrations of vitamin B12 may be due to underreporting supplement use, autoimmune disorders interfering with the B12 assay, or underlying renal or liver diseases

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Material and methods: The studies were conducted on laboratory animals, in this case male and female albino rats

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