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These arguments demonstrate that models of the methionine cycle need to be examined in greater detail to determine if (i) GSH does indeed accumulate under vitamin B 12 deficiency, (ii) if it does, how does vitamin B 12 deficiency induced hyperhomocysteinemia affect GSH levels
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Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: possible implications for susceptibility to amodiaquine-induced liver toxicity
