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The sample size included 478 AD (female: 318, male: 160) and 300 control (female: 148, male: 152) cases on which sex-stratified meta-analysis (Wan et al., 2020)

Altered functional connectivity within default mode network in patients with transient ischemic attack: a resting-state functional magnetic resonance imaging study
BMJ 312 , 12491253 (1996)

However, studies demonstrating the combinatory effects of HIV-Tat and alcohol/cigarette smoke on vascular endothelium are warranted to understand the CVD risk in HIV infected cigarette smokers or alcohol abusers
