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Additionally, these anti-obesity drugs have moved the goalpost for type 2 diabetes and should be considered initial therapy, allowing to attain diabetes reversal or remission which may no longer be the impossible dream to reach, said Rosenstock.

Similarly, triterpenoids have also gained attention for their various biological functions, including anti-inflammatory, antitumor, antiviral and antimicrobial activities ( H

The atherosclerotic plaques, especially the necrotic core of unstable plaques, contain apoptotic macrophages, erythrocytes and its metabolites - heme and hemoglobin (Li et al., 2006), and cytotoxic substances (cholesterol crystals, cholesterol esters, oxidized lipids, fibrin, inorganic minerals like hydroxyapatite, iron, and calcium) (Tong et al., 2023)

Therefore, severe SARS-CoV-2 infection has a strong potential to cause an acute stroke