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Importantly, dietary habits often remain unchanged after diagnosis, suggesting that nutritional management is underappreciated in clinical care [174]

Arnold and G

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Furthermore, given the aforementioned purported mechanisms for the improving effects of L-carnitine/synbiotics on weight or metabolic parameters, it could be conceived that concomitant supplementation of L-carnitine and synbiotics may confer more pronounced impacts on these indicators, potentially through simultaneous modulation of energy homeostasis (31, 33), or attenuating systemic inflammation (56, 57), in a complementary or synergistic manner probably mediated through concurrent targeting of metabolic/inflammatory signaling pathways including CPT-Ia (31, 37), AMPK (37), or NF-B (31, 34)