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Lucarini E, Micheli L, Toti A, et al
However, these mainstream therapies face critical limitations including the rapid emergence of drug resistance, FKS1/FKS2 gene mutations reducing -1,3-glucan synthase affinity, Targeted enzyme (Erg11p) modification, overexpression of efflux pumps (CDR1, MDR1), and upregulation of the ergosterol pathway mediate azole resistance (Pristov and Ghannoum, 2019)
In primary cultures of cortical neurons and astrocytes, inhibition of 26S proteasome activity by lactacystin (a non-peptidic proteasome inhibitor) resulted in a remarkable decrease in A42 degradation
Toh, LC
