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Quality issues from unreliable sources cause inconsistent results

This design is useful for generating preliminary evidence from real clinical practice, but it has limitations compared to a randomised controlled trial (RCT)

Nucleic Acids Research, 42(D1), D161D166

verify clarity before use Dosage Guidelines Typical adult regimen (per package insert): 100 mcg IM/SC daily for 67 days Then 100 mcg every other day for 23 weeks Maintenance with 100 mcg IM/SC monthly for life Adjust based on patient response and serum vitamin B levels Clinical Applications Used to correct symptomatic or laboratory-confirmed B deficiency, where rapid repletion is needed or oral supplementation is unreliable