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A Consensus Development Workshop, Baveno, Lake Maggiore, Italy, April 5 and 6, 1990

Furthermore, the design of unstructured and structured models of the bioprocess has allowed development of novel optimization strategies, closing the iteration-cycle between the in silico and in vivo approaches of analysis of this biotransformation process

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Key points No currently available oral or topical therapy is effective as a monotherapy, but some have shown encouraging results as a part of combination therapy