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Some improvements were noted in specific symptoms for female participants, particularly in reducing thirst and fatigue, but these effects were not significant across the broader participant group

[56] However, fair credit for the first description of Graves' disease goes to the 12th-century Persian physician Sayyid Ismail al-Jurjani, [57] who noted the association of goiter and exophthalmos in his Thesaurus of the Shah of Khwarazm , the major medical dictionary of its time

Acknowledgments The authors acknowledge funding support from the NIH (HL118369 to SKS and HL114643 to SR), from the American Heart Association (15GRNT25550051 to SKS) and a Burroughs Wellcome Career Award for Medical Scientists to SR

Choe, S.-Y