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P21 has similarly shown the ability to reverse dendritic and synaptic density loss caused by traumatic brain injury, restoring the physical architecture of neural connections that had been damaged

[DOI] [PubMed] [Google Scholar] 31.Ito Y, Yoshida H, Maruo R, Morita S, Takano T, et al

Visual Outcomes: The data revealed a visible reduction in dark spots, improved hyperpigmentation patches, and a more uniform overall skin clarity across diverse skin types

Curiously, inactivation of NgR-class receptors in the immune system, particularly CD4+ T cells, showed no effect, which may suggest that Nogo-A plays a minor role in peripheral cell activity, or that it may be almost fully dependent on a non-canonical receptor