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118 Following MI in mice, pJNK expression was increased in macrophages at the ischemic edge, the Wnt/PCP pathway was activated, and the Wnt/-catenin pathway was downregulated, which promoted the transformation of myeloid cells toward a proinflammatory state, thereby aggravating MI

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Similarly, in breast cancer, acacetin can promote the expression of RIPK1 and RIPK3 and the production of ROS, resulting in cell necroptosis (Kandhari et al., 2023)

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