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Description
Since the normality tests of the model residuals yielded a few significant results, we combined the permutation-based p value of the interaction term in the mixed-effects model with the FDR correction for multiple comparisons among multiple MRS measurements and/or brain regions

While a systematic review showed that kava does not have negative effects on cognition (37) , there have been case reports of impairment consistent with CNS depressant effects, including slow, slurred speech and flaccid muscle tone (45)

6) can influence HT pathogenesis
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they may be mild through to severe, impacting quality of life
