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The presence of a substantially larger and charged residue in LPLA2 (Arg214) relative to LCAT (Gly230) may discourage the binding of bulkier acyl acceptors such as secondary alcohols and sterols
But blood tests in people with Dercum's usually don't pick up signs of autoimmune activity or unusually high levels of inflammation

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397 In the nematode Caenorhabditis elegans , overexpression of ATGL or muscle-specific activation of protein kinase A extends lifespan