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In 3-AR knockout mice, however, no effect was observed with AOD9604 confirming the dependency of its chronic lipolytic action on 3-AR expression, while also suggesting an additional acute mechanism that may operate through a separate pathway

Together, these factors create a complex situation that results in considerable, yet avoidable suffering

In animal studies, Dihexa was found to be approximately 1,000 times more potent than BDNF (brain-derived neurotrophic factor) at promoting synapse formation

However, co-treatment with 1 M Dihexa and 10 M rapamycin showed significant attenuation of hair cell protection at 50 and 100 M neomycin
