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Description
This CRL, together with the ARIH1 RBR-type E3 ligase, along with cognate E2 ligases 10 , presumably polyubiquitylates AGO 34,35,36 , causing its degradation by the 26S proteasome and ultimately leaving the miRNA susceptible to cellular nucleases 10,11

Habermann, A

Produits complmentaires

Nat Rev Cancer (2010) 10(12):8717