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10.5897/AJB11.1024 Afr
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Increased levels of ROS and reactive nitrogen species have been reported in lung tissues of patients who died in fatal IV pandemics, while studies with IV-infected mice and cell lines also demonstrated an enhanced production of ROS and disturbance of antioxidant defence (Reference Buffinton, Christen and Peterhans37Reference Amatore, Sgarbanti and Aquilano39)
These patients have bioinactive growth hormone but, depending on the antigen used to develop the radioimmunoassay, they can have high concentrations of growth hormone in the presence of this poor growth and low IGF-I
