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The metabolism of essential fatty acids (EFAs) is particularly important, as the accumulation of lipid peroxidation is considered one of the major characteristics of ferroptosis [19]

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Arginine metabolic regulators such as spermidine have been shown to suppress M1 macrophage-associated cytokines while inducing M2 macrophage-related markers, significantly alleviating EAE symptoms, whereas Arg1 inhibitors can reverse these effects ( In other autoimmune diseases, amino acid metabolic reprogramming likewise participates in the formation of the inflammatory microenvironment by regulating macrophage polarization

Wang AJ, Tang Y, Zhang J, Wang BJ, Xiao M, Lu G, Li J, Liu Q, Guo Y, Gu J