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While inhibition of COX-1 can have serious gastrointestinal consequences, selective inhibition of COX-2 carries cardiovascular risks
Red cabbage rather than green cabbage increases stress resistance and extends the lifespan of Caenorhabditis elegans
This selectivity comes from the high expression of beta-3 adrenergic receptors in adipose tissue relative to other tissues
Conversely, M2-polarized macrophages secrete cytokines such as IL-10 and TGF-, which activate anti-ferroptotic signaling cascades within tumor cells
