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This form is responsible for maintaining the glutathione redox cycle in the cytoplasm, where numerous metabolic processes generate reactive oxygen species during normal cellular respiration and enzymatic reactions

It is based on the attachment of ligand to support that has not been specically functionalized for covalent attachment

Analysis scripts and notebooks used for this study are open-source and available from GitHub ( Any additional information required to reanalyze the data reported in this work paper is described in the Methods and available upon request from the corresponding authors

Finally, the review will discuss therapeutic strategies targeting GPX4 and ferroptosis, including pharmacological and gene therapies, and analyze the main challenges in this field and potential future research directions