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To establish a mouse model of hypercholesterolemia-induced atherosclerosis, we fed 8-week-old male LDLR / mice D12108 feed containing 1.25% cholesterol for 8 weeks

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References 1.Abraham NG, Kappas A (2008) Pharmacological and clinical aspects of heme oxygenase

This in turn is due to the fact that inhibitory influences from other parts of the brain on the pituitary gland diminish in the course of normal ageing, mainly because cortisol receptors there die off, so that it is practically feigned that there is too little cortisol "on the way"
