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Autocrine TGF-1/miR-200s/miR-221/DNMT3B regulatory loop maintains CAF status to fuel breast cancer cell proliferation

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On that basis, in a phase IIa clinical basket trial currently recruiting patients, low-dose IL-2 effects on regulatory T cells and clinical outcomes are being evaluated in chronic inflammatory barrier diseases including both patients with MMP and PV/PF (EU CTN: 2023-510297-14-00)

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