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Indeed, lithium therapy of cultured cerebellar granule cells increased mRNA and protein levels of Bcl-2, and the Bcl-2/Bax protein level ratio increased by 5-fold after treatment duration for 57 days 124

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During ferroptosis, Treg cells exhibit elevated mitochondrial superoxide (mitoSOX), disrupting OXPHOS and Fatty Acid Oxidation (FAO) - critical metabolic pathways that maintain Treg cells survival and suppressive function ( + T cells, potentiating anti-tumor immune responses

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