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Chronic flat GH exposure saturates hepatic IGF-1 production, desensitizes peripheral GH receptors, and drives water retention, carpal tunnel syndrome and insulin resistance at higher frequencies than pulsatile signaling does

While not every person benefits, and while nausea often resolves on its own after 2-3 weeks on a stable dose, any intervention that improves tolerability increases the likelihood that users remain on treatment long enough to achieve meaningful results

However, during other metabolic activities, NAD+ is consumed by NAD+-dependent enzymes and may subsequently become depleted over time, contributing to increased DNA damage, age-related illnesses and diseases, and mitochondrial malfunction