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Mechanistic analysis revealed that quercetin activates the Keap1Nrf2 pathway, upregulates downstream antioxidant genes ( nrf2 , ho-1 , sod , cat ), and increases SOD and catalase (CAT) activity, thereby eliminating excessive reactive oxygen species (ROS) and malondialdehyde (MDA)

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Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System

doi: 10.1038/s41419-020-03362-4
