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Increase in resting levels of superoxide anion in the whole blood of uremic patients on chronic hemodialysis

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Despite the promising results of GCGR-inhibition in animal models and clinical trials, no such therapies have been approved for clinical use due to adverse effects

[122][Level of evidence C2] Rates of clinically extensive GVHD and treatment-related mortality remain higher after unrelated donor transplant compared with matched sibling donor transplants.[61,78,115] However, there is some evidence that matched unrelated donor transplant may yield a lower relapse rate