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In people with insulin resistance or type 2 diabetes, GLP1 and GIP activity can support glucose-dependent insulin secretion, which means insulin release increases mainly when glucose is elevated

Elevated levels of MNAM were detected in the urine (Li et al., 2018) and serum (Souto et al., 2005) demonstrated an upregulation of NNMT expression in the WAT of individuals with IR or T2D

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