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Although some trials have not found benefit, considerable evidence suggests it also provides renal protection when given intravenously prior to coronary angiography

Front Pharmacol 5:151 Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J (1992) S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds

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This imbalance leads to widespread oxidative damage, including lipid peroxidation, which destabilizes neuronal membranes, protein oxidation, which results in the accumulation of toxic aggregates, and DNA damage, which triggers cell-death pathways [35,65,66,67,68,69,70] (Figure 1)