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Before large-scale clinical translation, two pharmacological bottlenecks must be solved: inadequate brain penetration and potential systemic toxicity
76 Didangelos, T
In this work, we firstly clarified that oridonin is a Michael acceptor molecule, reacting to thiol group of GSH by an electrophilic addition and covalent bonding
[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Garrow T.A., Brenner A.A., Whitehead V.M., Chen X.N., Duncan R.G., Korenberg J.R., Shane B
