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Mn 2+ could enhance the sensitivity of cGAS to dsDNA and augment STING signaling, which could further enhance the tumor-specific T cell-mediated immune response against poorly immunogenic solid tumors in vivo , offering a robust approach for immunotherapy in the clinics

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Potential culture methods Culture-based assays have the capacity to elucidate significant functional distinctions among individual microbial communities and help dissect differences in strain-level functional variation between individuals that drive health and disease outcomes