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Keywords: glutathione, oxidative stress, reactive oxygen species, nuclear factor erythroid 2-related factor 2, inflammaging, chronic obstructive pulmonary disease, atherosclerosis, COVID-19 Introduction Glutathione (GSH) is a unique molecule essential for life that participates in key aspects of cellular homeostasis, having a paramount role in defense against the oxidative damage that occurs during all different diseases including coronavirus disease 19 (COVID-19) disease