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Solution: Use payer-specific coverage guidelines to ensure that the diagnosis justifies the injectable drug

doi: 10.1016/j.jand.2015.08.002, 119

Using a combined transcriptomics and proteomics approach to analyse gene and protein expression in rectal biopsies of healthy individuals, sub-optimal Se status was found to be associated with inhibition of NF- B, IL-1 , IL-6 and TNF- signalling and down-regulation of immune and inflammatory response pathways (Reference Meplan, Johnson and Polley30)

In Figures 2A,B, the patients both have Hurley stage II but have moderate (Figure 2A) and severe (Figure 2B) IHS4, highlighting the importance of a dynamic scoring classification system