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Dendritic spines are highly specialized structures found at excitatory synapses, whose size and intracellular signaling in response to varying patterns of presynaptic input regulate synapse efficacy and plasticity

Dysbiosis, through the lack of appropriate immunoregulatory and barrier factors, such as, e.g., short-chain fatty acids, causes inappropriate activation of the immune system, resulting in epithelial inflammation, epithelial barrier damage and disease development [55, 57,58,59,60,61]

In addition, CJC-1295 and ipamorelin carry the same risk of milder side effects associated with many injectable peptides, namely injection site reactions and mild flu-like symptoms