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The need for diagnosis, treatment and prevention of AITD is also due to the need to prevent concomitant diseases, including disorders of the cardiovascular system, hypercholesterolemia, atrial fibrillation, encephalopathy, others autoimmune diseases ( Cellular and humoral immunity in the pathogenesis of AITD In addition to genetic, cellular and humoral immune mechanisms, loss of immune tolerance to thyroid autoantigens is the basis for the development of AITD

286 It reduces estrogen bioavailability, which can accelerate estrogen depletion and possibly trigger early menopause, as well as aggravate menopausal symptoms

Kugler, C

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