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Barinaga M, Yamonoto G, Rivier C, Vale W, Evans R, Rosenfeld M

A novel use of next-generation closed incision negative pressure wound therapy after major limb amputation and amputation revision

The results indicate a protective role of GSTP1 by enhancing GSH-conjugation, which might lead to a reduced protein modification, and suggest a second protective role by interfering with the unfolded protein response, thereby preventing apoptosis

rather, literature is providing the clue suggesting that it is a good endeavour to pursue in order to achieve an appropriate pharmacological target that could aim at reversing MetS in parallel with diet and exercise before it onsets T2D
