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Oxidants and Nonspecific Oxidative Damage to Lipids, Proteins, and DNA Recent developments have questioned the validity of the original concept of oxidative stress, particularly due to the realization that individual signaling and control events occur through discrete redox pathways rather than through mechanisms that are directly responsive to a change in the global thiol/disulfide balance (186)

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TAMs regulate tumor cell proliferation through numerous growth factors and receptors, including EGF, platelet-derived growth factor, transforming growth factor-1 (TGF-1), hepatocyte growth factor, epidermal growth factor receptor (EGFR) ligands, and basic fibroblast growth factor (42)

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