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Emerging evidence indicates that ferroptosis exerts significant effects not only in alveolar epithelial cells, fibroblasts, macrophages, and vascular endothelial cells but also orchestrates a range of processes including oxidative stress regulation, immune response modulation, barrier dysfunction, and tissue remodeling

Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts

31 Finally, tricellulin, an integral membrane protein contributing to the structure and function of tricellular contacts between neighboring cells, has a critical role in the formation of the epithelial barrier