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The effect occurred peripherally (i.e., the largest thrombosis initially (i.e., 25 mmHg) appeared just in the hepatic veins, resembling the presentation of BuddChiari syndrome (Gojkovic et al., 2020)), and centrally (superior sagittal sinus)

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Thinking one could substitute for the other in a research context would be a catastrophic error in study design

On the 5-Day Ausangate Trek, you hike through extreme landscapes: high valleys, colorful lagoons, glaciers, and mountain passes
