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In immune-competent cells PAMPs and DAMPs promote the synthesis of melatonin by activating the transcription of the gene that codifies AANAT

Compared to the control group, mice with DKD exhibited an increase in blood glucose after the second week and sustained a higher level during 12 weeks, whereas dapagliflozin-treated and insulin-treated mice with DKD showed a sustained decrease from week 10 and reached a stable level at week 16 (Figure 1A)

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[DOI] [PubMed] [Google Scholar] 8.Jorgensen P.H., Andreassen T.T., Jorgensen K.D