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Supporting our hypothesis, a recent longitudinal unbiased metabolomic study conducted in Sweden involving over 3200 adult men and women consuming a health-conscious food pattern at baseline sought to identify blood metabolites that could predict a lower risk of cardiovascular disease (CVD) and overall mortality (Reference Smith, Ottosson and Hellstrand17)

However, approximately one week postinjury, a shift in the microglial phenotype occurs at the damage site, resulting in reduced phagocytosis and increased production of proinflammatory cytokines and chemokines, as well as the recruitment of other immune populations [151, 152]