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However, downregulation of Groucho has been reported in colorectal cancer via the action of HDAC3 ( Epigenetic Regulation Downstream of Wnt Signaling Recent advances in cancer biology have identified the role of epigenetic regulation in cancers and numerous studies have identified mutations in the genes encoding both, the components and the regulators of Wnt signaling to aberrantly activate the Wnt signaling pathway in various cancers

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