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In addition, double knockouts of PGC-1 and PGC-1 in skeletal muscle or the adult heart did not result in a loss in mitochondrial mass, which indicated that PRC may play a role in mitobiogenesis in the absence of PGC-1 and PGC-1 [71, 72], a finding that warrants further investigation
WangNXieMLeiGZengCYangTYangZet al
BMJ Open 10 (11), e040527
Human StudiesWhat We Know Heres the catch: all of the research mentioned above has been done in animal models
