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Description
The defective TP caused by TYMP mutations leads to the excessive accumulation of nucleosides in both mitochondria and lysosomes

This renders traditional pills largely ineffective for the deep cellular repair needed in RA
Ann Clin Transl Neurol
Thus, while mitochondria are critical elements involved in the signaling cascade toward APAP-induced cell death, the organelle also plays an important role in the recovery and regeneration of liver function, especially in hepatocytes away from the central vein at the borders of the area of necrosis83
